Living inferiority

Inferiority Complex

Everyone starts life with some feelings of inferiority. Subsequent success or failure is determined by the ability to adjust the inferiority feeling to the demands of life. Normal development requires the recognition of one’s limitations and capacities in order to achieve a profitable balance in emotional maturity. The inferiority complex is different from the inferior feeling of which the form...

Non-Inferiority Logrank Tests

Individuals are recruited during an accrual period of R years (or months or days). They are followed for an additional period of time until a total of T years is reached. Hence, the follow-up period is T-R years. At the end of the study, the non-inferiority logrank test is conducted at significance level α with power 1− β . Under the proportion hazards assumption, the hazard ratio HR = h2 / h1 ...

Equivalence and non inferiority trials

Many effective drugs, biologics and devices exist. Because of this, it is often considered unethical to undertake placebo controlled clinical trials to evaluate new treatments. Rather, randomized active control noninferiority trials have become the norm. These trials, however, are accompanied by serious issues including selecting an active comparator, identifying previously run active comparato...

Assessing Equivalence and Non-Inferiority

Equivalence and Non-inferiority Trials of CAM

For several reasons, the value of placebo-controlled trials has often been disputed (not only) in complementary/alternative medicine (CAM) (1). Many clinicians feel that giving placebos to suffering patients is unethical. In fact, the Declaration of Helsinki advocates placebo-controlled trials only for conditions for which no therapy of proven efficacy exists (2). Other frequently cited reasons...